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Congratulations to everyone involved, especially De Lin for his heroic efforts for the new paper !

We have a new pre-print available! This project was looking at whether we could use the cIMS /ECD set up we have for HDX-MS to determine affinity constants (Kds) of protein:ligand complexes – turns out we could! More here: https://www.biorxiv.org/content/10.1101/2025.11.13.688232v1

Congratulations to Graham Neill who contributed to this wonderful collaboration with Simon Cook at the Babraham Institute, Cambridge to show how RAFi compounds can paradoxically activate GCN2. Published today in Nature Communications!

Vanesa Vinciauskaite has passed their viva today with flying colours. Thank you very much to Prof. Yogesh Kulathu and Dr Chloe Martens for being examiners and Prof. Albena Dinkova-Kostova for being convener. Vanesa is taking her HDX and Cryo-EM skills to GSK – well done!

A new collaborative study with Steve Jackson’s Lab is out today in Nature Communications, with beautiful data from PhD Student Vanesa Vinciauskaite : https://www.nature.com/articles/s41467-025-64050-5#citeas

The group welcomes Monika Petrova and Claudia Chau to the lab for their final year lab project, focusing on HRI inhibition. 👋

Congratulations to Graham Neill for passing his PhD viva today! Thank you to the examiners Dr Tony Ly and Dr Antonio Calabrese from Leeds! 🎉🎉🎉

Very happy to welcome Olawale to the lab, working with Miratual Muqit’s lab to explore HRI regulation.

Our latest research on how HRI is be inhibited by heme is now published in Biochemical Journal . Congratulations to Shivani and the team!

The lab welcomes Maureen who jobs the group as a research technician to work on GCN2 in mesothelioma cells, funded by Asthma + Lung UK.