New Pre-print: Spatially Resolved Determination of Small Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry

We have a new pre-print available! This project was looking at whether we could use the cIMS /ECD set up we have for HDX-MS to determine affinity constants (Kds) of protein:ligand complexes – turns out we could! More here: https://www.biorxiv.org/content/10.1101/2025.11.13.688232v1