A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Gong, Grace Q et al. Nature, 10.1038/s41586-023-05972-2. 24 May. 2023, doi:10.1038/s41586-023-05972-2
A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response Graham Neill, Masson GR. SYSTEMATIC REVIEW Front. Mol. Neurosci.
Fundamentals of HDX-MS. Vinciauskaite V, Masson GR.  Essays Biochem 2022; EBC20220111. doi: https://doi.org/10.1042/EBC20220111
GCN2: roles in tumour development and progression. Gold LT, Masson GR. Biochem Soc Trans. 2022 Apr 29;50(2):737-745. doi: 10.1042/BST20211252. PMID: 35311890 Free PMC article. Review.
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Heimhalt M, Berndt A, Wagstaff J, Anandapadamanaban M, Perisic O, Maslen S, McLaughlin S, Yu CW, Masson GR, Boland A, Ni X, Yamashita K, Murshudov GN, Skehel M, Freund SM, Williams RL. Elife. 2021 Sep 14;10:e68799. doi: 10.7554/eLife.68799. PMID: 34519269
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes. Ohashi Y, Tremel S, Masson GR, McGinney L, Boulanger J, Rostislavleva K, Johnson CM, Niewczas I, Clark J, Williams RL. Elife. 2020 Jun 30;9:e58281. doi: 10.7554/eLife.58281. PMID: 32602837
Towards a model of GCN2 activation. Masson GR. Biochem Soc Trans. 2019 Oct 31;47(5):1481-1488. doi: 10.1042/BST20190331. PMID: 31647517 Review.
Structural Mechanisms of PTEN Regulation. Masson GR, Williams RL. Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a036152. doi: 10.1101/cshperspect.a036152. PMID: 31636093 Review.
Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL. Science. 2019 Oct 11;366(6462):203-210. doi: 10.1126/science.aax3939. PMID: 31601764
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD. Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. PMID: 31249422 Review.
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria. Ravenhill BJ, Boyle KB, von Muhlinen N, Ellison CJ, Masson GR, Otten EG, Foeglein A, Williams R, Randow F. Mol Cell. 2019 Apr 18;74(2):320-329.e6. doi: 10.1016/j.molcel.2019.01.041. Epub 2019 Mar 7. PMID: 30853402
Activation of GCN2 by the ribosomal P-stalk. Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4946-4954. doi: 10.1073/pnas.1813352116. Epub 2019 Feb 25. PMID: 30804176
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System. Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M. Structure. 2018 Mar 6;26(3):446-458.e8. doi: 10.1016/j.str.2018.01.016. Epub 2018 Feb 22. PMID: 29478821
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling. Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ. Biophys J. 2017 Dec 5;113(11):2396-2405. doi: 10.1016/j.bpj.2017.09.018. PMID: 29211993
An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery. Masson GR, Jenkins ML, Burke JE. Expert Opin Drug Discov. 2017 Oct;12(10):981-994. doi: 10.1080/17460441.2017.1363734. Epub 2017 Aug 17. PMID: 28770632 Review.
Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry. Masson GR, Maslen SL, Williams RL. Biochem J. 2017 May 16;474(11):1867-1877. doi: 10.1042/BCJ20170127. PMID: 28381646
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Ohashi Y, Soler N, García Ortegón M, Zhang L, Kirsten ML, Perisic O, Masson GR, Burke JE, Jakobi AJ, Apostolakis AA, Johnson CM, Ohashi M, Ktistakis NT, Sachse C, Williams RL. Autophagy. 2016 Nov;12(11):2129-2144. doi: 10.1080/15548627.2016.1226736. Epub 2016 Sep 14. PMID: 27630019
Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry. Masson GR, Burke JE, Williams RL. Methods Mol Biol. 2016;1388:215-30. doi: 10.1007/978-1-4939-3299-3_14. PMID: 27033079
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. Protein Sci. 2016 Apr;25(4):826-39. doi: 10.1002/pro.2879. Epub 2016 Feb 1. PMID: 26756197
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity. Masson GR, Perisic O, Burke JE, Williams RL. Biochem J. 2016 Jan 15;473(2):135-44. doi: 10.1042/BJ20150931. Epub 2015 Nov 2. PMID: 26527737
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Rostislavleva K, Soler N, Ohashi Y, Zhang L, Pardon E, Burke JE, Masson GR, Johnson C, Steyaert J, Ktistakis NT, Williams RL. Science. 2015 Oct 9;350(6257):aac7365. doi: 10.1126/science.aac7365. PMID: 26450213
PTEN regulates cilia through Dishevelled. Shnitsar I, Bashkurov M, Masson GR, Ogunjimi AA, Mosessian S, Cabeza EA, Hirsch CL, Trcka D, Gish G, Jiao J, Wu H, Winklbauer R, Williams RL, Pelletier L, Wrana JL, Barrios-Rodiles M. Nat Commun. 2015 Sep 24;6:8388. doi: 10.1038/ncomms9388. PMID: 26399523
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors. Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL. Science. 2014 May 30;344(6187):1035-8. doi: 10.1126/science.1253397. PMID: 24876499
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA). Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. PMID: 22949682