The Glenn Robert Masson (GRM) Lab is interested in how nutrient deprivation impacts cancer cells, or, more specifically, how amino acid starvation triggers the Integrated Stress Response via the protein kinase GCN2.

We investigate this process in human tissues, cells, and at an atomic level using structural biology. One way we work on this problem is through Hydrogen Deuterium Exchange Mass Spectrometry (HDX).

We also develop small molecule drugs to target GCN2.

We are based at the University of Dundee, at the Jacqui Wood Centre for Cancer Research at the School of Medicine, and we are also associated with the Centre of Gene Regulation and Expression at the School of Life Sciences in Dundee.

We are always interested in enthusiastic post-docs or students working with us.

Contact Glenn if you’re interested in joining our lab.

News

Glacios Arrives

27/07/22 The new glacious screening microscope has arrived at the School of Life Sciences at the University of Dundee and Vanesa immediately got the ball rolling screening grids

Welcome to the Masson Lab

The Lab is interested in the amino acid starvation response and how that can be co-opted to develop novel treatments. We use all sorts of techniques to do this, not least structural mass spec. News: Read more…