Welcome to GRM Lab

The GRM Lab is interested in how nutrient deprivation impacts cancer cells, or, more specifically, how amino acid starvation triggers the Integrated Stress Response via the protein kinase GCN2. We investigate this process in human tissues, cells, and at an atomic level using structural biology. We also develop small molecule drugs to target GCN2.

A 3D Model of the translational stress sensing, intrinsically disordered P-Stalk protein complex.

We are based at the University of Dundee, at the Jacqui Wood Centre for Cancer Research at the School of Medicine, and we are also associated with the Centre of Gene Regulation and Expression at the School of Life Sciences in Dundee.

We are always interested in enthusiastic post-docs or students working with us. Contact Glenn if you’re interested in joining our lab.