GRM Lab

The Glenn Robert Masson (GRM) Lab is interested in how nutrient deprivation impacts cancer cells, or, more specifically, how different stresses triggers the Integrated Stress Response via the protein kinases GCN2 and HRI.

We investigate this process in human tissues, cells, and at an atomic level using structural biology. One way we work on this problem is through Hydrogen Deuterium Exchange Mass Spectrometry (HDX).

We also develop small molecule drugs to target GCN2 and HRI.

We are based at the Division of Cancer Research University of Dundee at the School of Medicine, and we are also associated with the Molecular, Cellular and Developmental Biology Division at the School of Life Sciences in Dundee.

We are always interested in enthusiastic post-docs or students working with us.

Contact Glenn if you’re interested in joining our lab.

News

New Paper: Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry

Congratulations to everyone involved, especially De Lin for his heroic efforts for the new paper !

New Pre-print: Spatially Resolved Determination of Small Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry

We have a new pre-print available! This project was looking at whether we could use the cIMS /ECD set up we have for HDX-MS to determine affinity constants (Kds) of protein:ligand complexes – turns out Read more

New Paper: RAF inhibitors activate the integrated stress response by direct activation of GCN2

Congratulations to Graham Neill who contributed to this wonderful collaboration with Simon Cook at the Babraham Institute, Cambridge to show how RAFi compounds can paradoxically activate GCN2. Published today in Nature Communications!