The Glenn Robert Masson (GRM) Lab is interested in how nutrient deprivation impacts cancer cells, or, more specifically, how different stresses triggers the Integrated Stress Response via the protein kinases GCN2 and HRI.
We investigate this process in human tissues, cells, and at an atomic level using structural biology. One way we work on this problem is through Hydrogen Deuterium Exchange Mass Spectrometry (HDX).
We also develop small molecule drugs to target GCN2 and HRI.
We are based at the Division of Cancer Research University of Dundee at the School of Medicine, and we are also associated with the Molecular, Cellular and Developmental Biology Division at the School of Life Sciences in Dundee.
We are always interested in enthusiastic post-docs or students working with us.
Contact Glenn if you’re interested in joining our lab.
Vanesa Vinciauskaite has passed their viva today with flying colours. Thank you very much to Prof. Yogesh Kulathu and Dr Chloe Martens for being examiners and Prof. Albena Dinkova-Kostova for being convener. Vanesa is taking Read more
A new collaborative study with Steve Jackson’s Lab is out today in Nature Communications, with beautiful data from PhD Student Vanesa Vinciauskaite : https://www.nature.com/articles/s41467-025-64050-5#citeas
The group welcomes Monika Petrova and Claudia Chau to the lab for their final year lab project, focusing on HRI inhibition. 👋