New pre-prints: GCN2 is activated by RAF inhibitors!

In collaboration with Dr Simon Cook’s group at the Babraham, we have discovered that several BRAF inhibitors can paradoxically activate GCN2. Using HDX-MS we were then able to dive into the structural basis of how these compounds work – they seem to poke the kinase into action via the HisRS domain! Two preprints can be found here and here!