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GCN2: roles in tumour development and progression 

Gold, Lyssa T., Masson, Glenn R. Biochem Soc Trans (2022) BST20211252.


Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Heimhalt, Maren et al. eLife vol. 10 e68799. 14 Sep. 2021, doi:10.7554/eLife.68799


Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes eLife Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, et al. eLife 2020;9:e58281


Structural Mechanisms of PTEN Regulation Cold Spring Harbor Perspectives in Medicine

Biochemical Transactions Review: Towards a model of GCN2 Activation

Architecture of human Rag GTPase heterodimers and their complex with mTORC1 Madhanagopal Anandapadamanaban, Glenn R. Masson… Science  11 Oct 2019: Vol. 366, Issue 6462, pp. 203-210 DOI: 10.1126/science.aax3939

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.  Glenn R. Masson et al. Nature Methods, 16, 595-602 (2019) PMID: 31249422 DOI: 10.1038/s41592-019-0459-y

The cargo receptor NDP52 initiates selective autophagy by recruiting the ULK complex to cytosol-invading bacteria. Ravenhill, BJ., Boyle, KB., von Mühlinen, N., Ellison, CJ., Masson, GR., Otten, EG., Foeglein, A., Williams, R., Randow, F. Molecular Cell, 74: 1-10.

Activation of GCN2 by the ribosomal P-stalk Glenn R. Masson & Inglis, A.J.,  Shao S., Perisic, O., McLaughlin, S.H., Hegde,  S.R., Williams, R.L.


Bunney T.D. et al. Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System Structure doi:


Thomas Buckles, Brian Ziemba, Glenn Masson, Roger Williams, Joeseph Falke. Mechanism by which Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling: A Single-Molecule Study. Biophysical Journal  Biophys J. 2017 Dec 5;113(11):2396-2405. doi: 10.1016/j.bpj.2017.09.018.

Masson GR, Jenkins ML, Burke JE. An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discoveryExpert Opinion in Drug Discovery 

Free copy of review:

Glenn R. Masson, Sarah L. Maslen, Roger L. Williams. Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron transfer dissociation hydrogen/deuterium exchange mass spectrometry Biochemical Journal


Yohei Ohashi, Nicolas Soler, Miguel García Ortegón, Lufei Zhang, Marie L. Kirsten, Olga Perisic, Glenn R. Masson, John E. Burke, Arjen J. Jakobi, Apostolos A. Apostolakis, Christopher M. Johnson, Maki Ohashi, Nicholas T. Ktistakis, Carsten Sachse & Roger L. Williams. Characterisation of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 Complex. Autophagy
Ziemba BP, Burke JE,  Masson G, Williams RL, Falke JJ. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophysical Journal. 2016 April 26; 110(8): 1811-25 doi: 10.1016/j.bpj.2016.03.001

Glenn R. Masson, John E. Burke, Roger L. Williams. PTEN: Methods and Protocols. Chapter 14: Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry. Humana Press. pp. 215-230.  doi: 10.1007/978-1-4939-3299-3_14.

Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11Protein Sci. 2016 Jan 12. doi: 10.1002/pro.2879


Glenn R. Masson, Olga Perisic, John E. Burke, Roger L. Williams. The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity. Biochemical Journal 

Ksenia RostislavlevaNicolas SolerYohei OhashiLufei ZhangEls PardonJohn E. BurkeGlenn R. MassonChris JohnsonJan SteyaertNicholas T. KtistakisRoger L. WilliamsStructure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science 

Iryna Shnitsar, Mikhail Bashkurov, Glenn R. Masson, et alPTEN regulates cilia through Dishevelled. Nature Communications 


John E. Burke,  Alison J. Inglis, Olga Perisic, Glenn R. Masson, Stephen H. McLaughlin, Florentine Rutaganira, Kevan M. Shokat, and Roger L. Williams. Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectorsScience 


Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA). PNAS.